A fire needs three things at once: fuel, heat, and oxygen (an oxidiser). Remove any one and it can’t burn — that’s the fire triangle.
The Apollo 1 tragedy showed the stakes: a spark in a pure-oxygen cabin caused a fire that killed three astronauts during a ground test. NASA later switched ground tests to a nitrogen–oxygen mix.
A key NASA finding: oxygen concentration matters more than partial pressure for flammability. A higher percent oxygen raises fire risk faster than a higher partial pressure does. So a designer wants to keep the oxygen fraction as low as human health allows.